Research in Prevention and Treatment of Noise-Induced Hearing Loss (NIHL)
Annual rept. 1 Apr 2013-31 Mar 2014
SOUTHERN ILLINOIS UNIV SCHOOL OF MEDICINE SPRINGFIELD
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The current study will identify D-methionine D-met dose and delayed time otoprotective response from steady state and impulse noise-induced hearing loss NIHL. The second year was dedicated to determining the latest time D-met may be administered for efficient protection. Groups of Chinchillas laniger n 10 received five intraperitoneal D-met 200 mgkgdose every 12 hours beginning 7, 9, 12, 18, 34, 36, or 48 hours after steady state or impulse. D-met otoprotection was assessed by auditory brainstem response ABR analysis and outer hair cell OHC quantification. ABR analyses identified time-dependent D-met protection from steady state and impulse noise exposures when D-met administration began as late as 24 hours post-noise exposure. Histological cytocochleogram analysis is still in progress to confirm electrophysiological assessment. Statistical analysis is currently in progress.
- Anatomy and Physiology