Governance of Cutaneous Photocarcinogenesis by Chronic UVA-Exposed Dermal Fibroblasts
Final rept. 1 Jul 2010-30 Jun 2014
MASSACHUSETTS GENERAL HOSPITAL BOSTON
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Long-wave ultraviolet A UVA is the major component of terrestrial UV radiation and is also the predominant constituent of indoor sunlamps, both of which have been shown to increase cutaneous melanoma risk. Using a 2-chamber model, we show that UVA-exposed target cells induce an intercellular oxidative signaling to non-irradiated bystander cells. This UVA-mediated bystander stress is observed between all three cutaneous cell types i.e. keratinocytes, melanocytes and fibroblasts. Significantly, melanocytes appear to be more resistant to direct UVA effects compared to keratinocytes and fibroblasts although melanocytes are also more susceptible to bystander oxidative signaling. The extensive intercellular flux of oxidative species has not been previously appreciated and could possibly contribute to the observed cancer risk associated with prolonged UVA exposure, such as those associated with indoor tanning.
- Medicine and Medical Research