Prevention of the Post-traumatic Fibrotic Response in Joints
Annual rept. 30 Sep 2013-29 Sep 2014
THOMAS JEFFERSON UNIV PHILADELPHIA PA
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The ongoing study addresses the critical clinical problem of posttraumatic joint stiffness, a pathology that reduces the range of motion ROM of injured joints and contributes to the development of osteoarthritis. The fundamental hypothesis that drives the current study is that pathological fibrotic response of injured joint tissues may be limited by targeting the formation of collagen fibrils, a main component of the fibrotic mass. Key preliminary data indicate the following i in comparison to the non-treated control, deposition of newly-formed collagen fibrils in posterior capsules from injured knees of rabbits treated with the anti-fibrotic antibody is reduced significantly, ii in comparison to the non-treated control, the correct collagen IIIcollagen I ratio in posterior capsules from injured knees of rabbits treated with anti-fibrotic antibody is maintained, iii in comparison to the non-treated control, the ROM of injured knees of rabbits treated with anti-fibrotic antibody is greater. Ongoing studies with additional groups of animals will determine the statistical significance of the differences observed in the measured parameters. Completion of these experiments will define the utility of the anti-collagen I antibody to block excessive fibrosis associated with joint injury.
- Anatomy and Physiology
- Medicine and Medical Research