Elucidation of Molecular Alterations in Precursor Lesions of Ovarian Serous Carcinoma
Final rept. 1 Jul 2009-30 Jun 2013
JOHNS HOPKINS UNIV BALTIMORE MD
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The objectives are to 1 elucidate the pathogenesis of ovarian cancer by characterizing the early lesions, and 2 to provide biomarkers for early ovarian cancer detection. Both goals will be facilitated by the Consortium Development plan which is a collaborative, interdisciplinary program that will establish the infrastructure to coordinate research. The research sites include Johns Hopkins University, Toronto University, Memorial Sloan Kettering Cancer Center, and Yale University. The Coordination center will have three Cores. The specific goals to be accomplished are briefly summarized. The Administrative Core will collect IRB protocols from all research sites, organize the Consortium symposium including the PathologyEpidemiology consensus meeting, setup and test the audio-video broad band electronic device for e-conference, organize the Internal Advisory Board. The PathologyEpidemiology Core will define criteria for early ovarian cancer lesions and select casescontrols, survey available cases and controls from all research sites, create one overall database for specimens with clinical and epidemiologic data, establish tissue tracking mechanisms. The Biostatistics Core will establish the data collection, storage and security system, and perform statistics support in study design. The completion of these tasks is considered critical for us to continue our research in the coming Consortium research program.
- Genetic Engineering and Molecular Biology
- Anatomy and Physiology
- Medicine and Medical Research