Toxicity Evaluation of Engineered Nanomaterials: Portable In Vitro Chamber to Study Realistic Occupational Exposure in Biological Systems (Phase 2 Studies)
Final rept. 21 Jan 2009-31 Dec 2011
AIR FORCE RESEARCH LAB WRIGHT PATTERSON AFB OH HUMAN PERFORMANCE WING (711TH) HUMAN EFFECTIVENESS DIR/ BIOEFFECTS DIVISION
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The project entitled Toxicity Evaluation of Engineered Nanomaterials Portable In Vitro Chamber to Study Realistic Occupational Exposure in Biological Systems focused on developing a fundamental understanding of the interaction of nanomaterials NMs with biological molecules and provides instrumentation and field methodology design to mimic realistic exposure scenarios to predict the toxicological effects of engineered NMs upon occupational human exposure. Although many studies are being conducted to investigate the toxicity of NMs, traditional techniques do not mimic realistic exposures, which can yield contradictory and inconclusive lab experimental results. This study describes the methodology necessary for mimicking realistic NM exposure, in addition to in situ NM characterization and toxicity kinetics and mechanisms. The final objective is to collect relevant toxicological data to support high accuracy predictive power for human risk assessment.
- Anatomy and Physiology
- Medicine and Medical Research
- Miscellaneous Materials