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Development and Testing of Iron Based Phantoms as Standards for the Diagnosis of Microbleeds and Oxygen Saturation with Applications in Dementia, Stroke, and Traumatic Brain Injury

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Annual rept. 29 Sep 2013-29 Sep 2014

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As our project was suspended since the fifth quarter due to insufficient funds in this second year, here we will report our findings during the fifth quarter. Nonetheless, we still have some potable outcomes to report toward the end of this report. We have now understood better about the slight disagreements or inconsistencies between CISSCO results and phase values inside straws. The problem is due to interactions between particles or molecules and water. From the past literature, this is called hyperfine shifts in NMR studies. All of our re-analyzed results from gadolinium and ferritin solutions are consistent between different echo times from MRI measurements, but results from calcium solutions remain inconsistent. In fact, results from calcium solutions do not seem repeatable. This may be due to very high concentrations of calcium solutions at least 5 in volume. CISSCO results from low concentration nanoparticle solutions also agree with phase values inside straws but accuracies become an issue. Also in the fifth quarter, from a phantom study with one straw in the phantom, we have compared results from CISSCO, SWIM, and a quantitative susceptibility mapping QSM method from the Cornell group. Results from CISSCO are consistent and accurate but results from SWIM and Cornell QSM are not. Lastly, we have applied the 3D CISSCO method for the susceptibility quantifications of some air bubbles and glass beads.

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  • Biochemistry
  • Anatomy and Physiology
  • Medicine and Medical Research
  • Inorganic Chemistry

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