RNA Chimeras as a Gene Signature of Breast Cancer
Annual rept. 15 May 2013-14 May 2014
MINNESOTA UNIV MINNEAPOLIS
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This project is set to test a hypothesis that breast cancer may express many RNA chimeras not only because there are fusion genes derived from chromosomal translocation or rearrangement but also because of abnormal trans-splicing of RNA transcripts. Many of these RNA chimeras may influence the behaviors of breast cancer via undiscovered mechanisms. One of the astonishing finding in 2012 fiscal year is the fusion RNAs formed between the nuclear RNA nRNA and mitochondrial RNA mtRNA. Because such fusion, if it indeed exists in human cells, discloses a series of novel RNA processing mechanisms, in the past year we put much effort to analyze it and publish it. The major results from the work in the past year are summarized below.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research