Accession Number:

ADA612001

Title:

Kelvar Vest Protection Against Blast Overpressure Brain Injury: Systemic Contributions to Injury Etiology

Descriptive Note:

Annual rept. 1 May 2012-30 Apr 2013

Corporate Author:

GENEVA FOUNDATION TACOMA WA

Personal Author(s):

Report Date:

2013-05-01

Pagination or Media Count:

10.0

Abstract:

The etiology of blast-induced traumatic brain injury bTBI is largely undefined. Along with reducing mortality, in preliminary experiments Kevlar vests significantly protected against bTBI in rats. We postulate that 1 blast-induced fiber degeneration in brain results from pressure surges transmitted through the vasculature that elicit intracranial disruptions, and 2 Kevlar vests are neuroprotective by uncoupling this pressure transmission following exposure to blast. Using a compression driven shock tube, we compare external, systemic e.g. vascular, and central e.g. intracranial pressure BOP-induced pressure changes, and assess the impact of Kevlar vests on these changes. We seek to 1 determine if measured pressure changes are blast severity-dependent and correspond with outcome measures, and 2 assess the impact of Kevlar vests on measured BOP-induced pressure changes and outcome measures and establish whether a protective vest encasing the thorax ameliorates blast-induced brain injury, pointing to a contribution of the effects of blast on the thorax to brain injury. These studies will provide insights into the etiology of blast-induced brain injury and will advance the development of mitigation strategies.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research
  • Explosions
  • Protective Equipment

Distribution Statement:

APPROVED FOR PUBLIC RELEASE