Breast Tumor Ablation by Selective Autophagic Degradation of Postmitotic Midbodies
Final rept. 1 May 2012-30 Apr 2014
MASSACHUSETTS UNIV MEDICAL CENTER WORCESTER
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Breast cancer develops from epithelial lesions in breast ducts and lobules that become invasive and can be metastatic. Breast cancer is a disease of uncontrolled cell division. Cell division normally creates two genetically identical daughter cells through severing of a cytoplasmic bridge that interconnects them. The midbody is an organelle involved in severing. Previously midbodies were thought to be lost from cells after division, but we show they can be retained. Here we show breast cancer oncogenes, tumor suppressors and breast cancer stem cells Task 1. They are scaffolds for anchoring breast cancer oncogenes, tumor suppressors and breast cancer stem cell proteins. Increasing MB cells increases in vitro tumor potential Task 2. We activated a MB-degradation pathway that decreased MBs and tumorigenic properties of breast cancer cells Task 3. Because MBs are in breast cancer stem cells, we believe this MB targeting strategy may be an innovative strategy for therapies focused on the most difficult of all tumors, those thought to be caused by cancer stem cells, namely recurrent, resistant and metastatic cancers.
- Anatomy and Physiology
- Medicine and Medical Research