Accession Number:

ADA611880

Title:

New Methods of Low-Field MRI for Application to Traumatic Brain Injury

Descriptive Note:

Annual rept. 10 Jan 2013-9 Jan 2014

Corporate Author:

HARVARD UNIV CAMBRIDGE MA

Personal Author(s):

Report Date:

2014-04-01

Pagination or Media Count:

111.0

Abstract:

We are developing robust low-magnetic-field implementations of MRI LFI focused on brain imaging with two complimentary test scanner systems electromagnet and permanent magnet based. We have also developing injury-sensitive MRI based on the detection of free radicals associated with injury using the Overhauser effect and subsequently imaging that modified nuclear polarization using low-field MRI OMRI. We have been optimizing imaging sequences, image reconstruction, and parallel imaging based acceleration in this unique regime. Results include demonstration of 3D human brain imaging in the electromagnet LFI at 6.5 mT, 2D imaging in a 100 lb scanner based on a rotating permanent magnet array, and free-radical imaging ex vivo as a path toward in vivo applications. Application of the suite of techniques and technologies from our work could advise future development of a deployable device with a high diagnostic impact, transforming diagnosis and monitoring of secondary injury prevalent in TBI.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE