Accession Number:

ADA611661

Title:

Development of Modified Titanium Nitride Nanoparticles as Potential Contrast Material for Photoacoustic Imaging

Descriptive Note:

Final rept. 6 Mar 2013-5 Mar 2014

Corporate Author:

TEL-AVIV UNIV (ISRAEL)

Personal Author(s):

Report Date:

2014-05-10

Pagination or Media Count:

17.0

Abstract:

The focus of this project was to develop synthetic methodologies and evaluate Titanium Nitride TiN-based nanomaterials, as prospective contrast agents for Photoacoustic PA Tomography, according to the following program 1. Development of methodologies for preparation of stable nano-suspensions of TiN nanoparticles TiN NPs in physiological solution and plasma, by using natural and synthetic dispersants. 2. Development of methodologies for preparation of TiN NPs nano-suspensions based on modification of TiN NPs by molecules capable of binding to TiN NPs and having biological receptor-targeting moieties. 3. Testing stability of the receptor-targeted TiN NPs nano-suspensions in physiological solution and in plasma. 4. Evaluation of cell-binding capabilities of the receptor-targeted TiN NPs vs. non-targeted TiN NPs in relevant cellular models.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE