Extended Storage of Pathogen-Reduced Platelet Concentrates (PRECON)
Annual rept. 26 Sep 2013-25 Sep 2014
PUGET SOUND BLOOD CENTER SEATTLE WA
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This grant pertains to increasing the availability and safety of platelets for transfusion. Ultimately our project proposes to determine the efficacy of using a pathogen inactivation technique Mirasol coupled with a Platelet Additive Solution PAS to extend the life of platelet concentrates. Preliminary steps to this ultimate goal are to determine the best storage bag and the optimum PAS to plasma ratio to utilize in our Mirasol experiments. Once we have established the optimum storage bag and PAS concentration we will evaluate the effects of Mirasol treatment on extended storage of PAS-stored platelet concentrates prepared from treated WB. These studies will be conducted using healthy donor autologous radiolabeled stored versus fresh platelet recovery and survival measurements to identify storage conditions that meet FDA post-storage platelet viability criteria. Thereafter, we will determine the post-transfusion recovery and survival of pre-storage pooled extended stored platelet concentrates prepared from Mirasol-treated WB given to thrombocytopenic patients.
- Medicine and Medical Research