Protective Role of Ets1 in SLE
Final rept. 1 Jul 2011-30 Jun 2014
BRIGHAM AND WOMENS HOSPITAL BOSTON MA
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Single nucleotide polymorphisms SNP at ets1 locus have been shown to increase the risk of SLE. Ets1-deficient mice display a few autoimmune features similar to SLE and their T cells produce an abnormally high level of IL-10 and a low level of IL-2, two features reminiscent of those of T cells of lupus patients. Ets1 directly binds to the il10 gene and recruited histone deacetylase, thereby suppressing the expression of IL-10. In contrast, Ets1 promotes IL-2 expression by an NFAT-dependent mechanism. We further found that the level of Ets1 in peripheral blood was negatively correlated with the level of anti-dsDNA. Our preliminary data suggest that Ets1 acts synergistically with Fc IIbR in counteracting the autoimmune process of SLE. Future direction is to investigate the molecular mechanism mediating the synergistic effect between Ets1 and Fc IIbR.
- Medicine and Medical Research