The Role of IL-17 in the Angiogenesis of Rheumatoid Arthritis
Final rept. 1 Jul 2010-30 Jun 2014
ILLINOIS UNIV AT CHICAGO
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In this proposal we show that ligation of IL-17 to IL-17R plays a critical role in rheumatoid arthritis RA joint vascularization. However, less is known about the pro-angiogenic factors downstream of IL-17 cascade that could indirectly contribute to RA angiogenesis. In this progress report, we discovered a novel chemokine CCL28 and its corresponding receptor CCR10 that is modulated by IL-17 in RA myeloid cells. We uncover for the first time the expression pattern, regulation and function of this IL-17 downstream pathway. We further provide strong evidence that supports utilizing the CCL28CCR10 cascade as a potential therapeutic target in RA. These findings were recently published in the highest ranked rheumatology journal Annals of Rheumatic Disease and the discoveries were highlighted in 11 other scientific journals.
- Medicine and Medical Research