Accession Number:

ADA611428

Title:

The Role of IL-17 in the Angiogenesis of Rheumatoid Arthritis

Descriptive Note:

Final rept. 1 Jul 2010-30 Jun 2014

Corporate Author:

ILLINOIS UNIV AT CHICAGO

Report Date:

2014-07-01

Pagination or Media Count:

84.0

Abstract:

In this proposal we show that ligation of IL-17 to IL-17R plays a critical role in rheumatoid arthritis RA joint vascularization. However, less is known about the pro-angiogenic factors downstream of IL-17 cascade that could indirectly contribute to RA angiogenesis. In this progress report, we discovered a novel chemokine CCL28 and its corresponding receptor CCR10 that is modulated by IL-17 in RA myeloid cells. We uncover for the first time the expression pattern, regulation and function of this IL-17 downstream pathway. We further provide strong evidence that supports utilizing the CCL28CCR10 cascade as a potential therapeutic target in RA. These findings were recently published in the highest ranked rheumatology journal Annals of Rheumatic Disease and the discoveries were highlighted in 11 other scientific journals.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE