Characterizing and Targeting Replication Stress Response Defects in Breast Cancer
Annual rept. 15 Jul 2013-14 Jul 2014
M D ANDERSON CANCER CENTER HOUSTON TX
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During the fourth year of this project, we have made significant progress in several of our proposed tasks. We found that TUSC4 is a potent tumor suppressor gene in breast cancer its deficiency alone can sufficiently transform normal breast epithelial cells and promote tumor growth in mice. We further demonstrated that mechanistically TUSC4 protects BRCA1 protein from degradation by interfering its binding to Herc2 E3 ligase. In addition, we have validated the in vivo effects of MEK inhibitor, AZD6244 on targeting RSRD breast cancer cells in a xenograft mouse model. Finally, we have successfully optimized and reduced the size of hallow gold nanoparticle HAuNS and modified a functional group of AZD6244 so it can be conjugated to HAuNS.
- Medicine and Medical Research