Prenatal Antidepressants and Autism Spectrum Disorder
Annual rept. 1 Sept 2013-31 Aug 2014
CHILDREN'S HOSPITAL MEDICAL CENTER CINCINNATI OH
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According to the CDC Autism Spectrum Disorder ASD prevalence has risen to 166, but its causes remains unclear. Croen et al. 2011 reported an increase in ASD in children whose mother s took SSRI antidepressants ADs during pregnancy. We are testing this hypothesis in rodents. The study is a 2-year long experiment to be decoded and analyzed in YR02. Groups treated during gestation and lactation are saline SAL, citalopram CIT, fluoxetine FLX, bupropion DUP, and a newly added positive control group given valproic acid VPA on E12 only. There will be 20 littersgroup except CIT10 with 10 for a total of 110 litters x8 offspringlitter880 progeny. All ADs caused unexpected skin irritation which is being successfully treated with a 1.5 topical lidocaine spray. Current number of sperm-positive females enrolled SAL12, CIT1010, CIT511, FLX511, BUP1512, and VPA50010 total66 litters 528 offspring, leaving 44 more litters yet to be enrolled. Litters completed SAL6, CIT105, CIT54, FLX6, BUP6, and VPA5003 total30, leaving 80 litters still in testing or yet to be enrolled totally 640 progeny. Given the current rate of enrollment, the last litter is to be enrolled in February 2015 and the last litter to finish testing by the end of March 2015.
- Medicine and Medical Research