Maximizing PTH Anabolic Osteoporosis Therapy
Annual rept. 15 Aug 2013-14 Aug 2014
INDIANA UNIV INDIANAPOLIS
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The subject of this research is the need for improved osteoporosis therapies. The purpose of this study is to test the efficacy of parathyroid hormone PTH mono-therapy and PTH antiresportive combination therapies on Nmp4-knockout KO and wild type WT mice. The scope of the research comprises the following specific aims i ii to determine the impact of Nmp4 on the efficacy of PTH mono- and combination therapies with bisphosphonates and the selective estrogen receptor modulator SERM raloxifene in ovariectomized ovx mice iii to determine the cell type-specific contributions to the enhanced response of the Nmp4-KO mouse to these osteoporosis therapies.
- Anatomy and Physiology
- Medicine and Medical Research