Accession Number:

ADA610951

Title:

Maximizing PTH Anabolic Osteoporosis Therapy

Descriptive Note:

Annual rept. 15 Aug 2013-14 Aug 2014

Corporate Author:

INDIANA UNIV INDIANAPOLIS

Personal Author(s):

Report Date:

2014-09-01

Pagination or Media Count:

43.0

Abstract:

The subject of this research is the need for improved osteoporosis therapies. The purpose of this study is to test the efficacy of parathyroid hormone PTH mono-therapy and PTH antiresportive combination therapies on Nmp4-knockout KO and wild type WT mice. The scope of the research comprises the following specific aims i ii to determine the impact of Nmp4 on the efficacy of PTH mono- and combination therapies with bisphosphonates and the selective estrogen receptor modulator SERM raloxifene in ovariectomized ovx mice iii to determine the cell type-specific contributions to the enhanced response of the Nmp4-KO mouse to these osteoporosis therapies.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE