A Model for Predicting Cognitive and Emotional Health from Structural and Functional Neurocircuitry Following Traumatic Brain Injury
Annual rept. 15 Sep 2012-14 Sep 2013
MCLEAN HOSPITAL BELMONT MA
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Mild traumatic brain injury mTBI is one of the major health problems facing military servicemembers returning from deployments. White matter axonal damage, as measured by neuroimaging techniques like Diffusion Weighted Imaging DWI, is one of the hypothesized mechanisms contributing to the cognitive and affective sequalae of mTBI. Presently, many of the findings in the literature examining the association between DWI and neuropsychological outcome are contradictory, possibly due to differences in stage of recovery at the time of assessment. This study will address this problem by collecting measures of white matter integrity and concomitant neuropsychological status at five time points in the first year following an mTBI. Study preparations, including ethical approval, hiring and training of new staff, purchasing of equipment and materials, and validation of neuroimaging protocols, were completed ahead of schedule. Data collection is currently underway, but was recently slowed due to some technical issues with the scanner, but these have been resolved and we now have completed collection of 10 participants. The data are entered in a database, and data quality is monitored closely. The small sample size does not permit a meaningful data analysis yet. Overall, the study is progressing within expected limits.
- Medicine and Medical Research