Temporal Progression of Visual Injury from Blast Exposure
Annual rept. 1 Sep 2012-31 Aug 2013
UTAH UNIV SALT LAKE CITY
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The purpose of this grant is to investigate the temporal progression of eye injury from blast exposure and identify early predictors of visual dysfunction. We propose to accomplish this by first identifying the probability of military personnel developing visual system injury after blast exposure, and determining the time point after blast exposure that visual system injury becomes identifiable. In parallel to the clinical studies, we propose to systematically evaluate the time course of visual system injury from blast exposure using our existing rat model for blast traumatic brain injury. From the studies performed in the previous year, we have found that low-level blast exposure 225 kPa in rats appears to result in a general decrease in visual acuity without any signs of stress or pain in the animals.
- Medicine and Medical Research