Accession Number:

ADA610840

Title:

Genetic Networks Activated by Blast Injury to the Eye

Descriptive Note:

Annual summary rept. 15 Jul 2012-14 Jul 2013

Corporate Author:

TENNESSEE UNIV CENTER FOR THE HEALTH SCIENCES MEMPHIS

Personal Author(s):

Report Date:

2013-08-01

Pagination or Media Count:

26.0

Abstract:

The present research project is designed to define the overall change in gene expression in the eye following a blast injury to the eye. In this process the genetic networks activated by injury will be defined along with biological markers of retinal injury. Scope The proposal will examine the changes in gene expression that occurs in a mouse genetic reference panel, the BXD recombinant inbred RI strain set. This analysis will define genomic loci modulating the response of the eye to a blast injury and the genetic networks activated by the injury. Major Finding A new microarray platform, Affymetrix GeneChip ST 2.0 Mouse Array, with over 28,000 protein-coding genes and 7,000 non-coding RNAs will be used to define the genetic response of the eye to blast injury. This has required the incorporation of a completely new annotation platform in our website GeneNetwork.org to accommodate the new DoD TATRC Retina Database. We will release the first version of the normal data within the next few months. We have defined a novel marker for retinal ganglion cell injury Sox11. This work has led to a series of investigations to define the molecular networks activated by Sox11.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE