Twisted Gastrulation as a BMP Modulator during Mammary Gland Development and Tumorigenesis
Annual summary rept. 1 Mar 2011-28 Feb 2014
MINNESOTA UNIV MINNEAPOLIS
Pagination or Media Count:
BMP activity is tightly regulated at extracellular and intracellular levels of signaling as the dosage of BMPs can have widely varied effects depending on the time, tissue and domain in which they are expressed. However, the regulation of BMP signaling within the MG, both during normal development and oncogenesis, remains largely unknown. Twisted gastrulation TWSG1 is a conserved extracellular modulator of BMPs. It can promote or inhibit BMP signaling depending on the constituents of the extracellular milieu. Twsg1 is expressed in mammary glands from wild type WT mice at 3, 6 and 8 weeks of life, and is differentially expressed in breast cancer, yet its role in MG development and breast cancer pathogenesis is unknown. This study is designed to determine how TWSG1 regulates the invasion of normal MG tissue during ductal elongation and the behavior of breast cancer cells.
- Medicine and Medical Research