The Role of NF1 in Memory Retrieval
Final rept. 15 Jun 2010-14 Jun 2014
COLD SPRING HARBOR LAB NY
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This three year grant supports our efforts in studying a role of the neurofibromatosis type 1 NF1 gene in mediating retrieval of long term memory. Our investigation over the entire funding period leads to following discoveries. First, NF1 is critical for supporting multiple types of longterm memories, including aversive and appetitive classic conditioning. Second, it regulates memory bi directionally. A loss of NF1 functions attenuates LTM while overexpression of NF1 enhances memory. Thus, memory strength is proportional to the amount of NF1 expressed. Third, NF1 s functions within octopamine neurons are involved in supporting long term memory. Silencing NF1 functions targeted to this group of neurons impairs memory. Manipulation of neuronal activity within this subgroup of neurons impact critically on memory strength within a time window after memory consolidation has been completed. Although these findings favor our hypothesis, we still cannot conclude that NF1 mediates retrieval of long term memory. More investigation is needed to complete the proposed study and to make conclusion on role of NF1 in memory retrieval.
- Medicine and Medical Research