Accession Number:

ADA610693

Title:

Clinical Development of Gamitrinib, a Novel Mitochondrial-Targeted Small Molecule Hsp90 Inhibitor

Descriptive Note:

Annual rept. 1 Sep 2013-31 Aug 2014

Corporate Author:

WISTAR INST OF ANATOMY AND BIOLOGY PHILADELPHIA PA

Personal Author(s):

• Altieri, Dario C.

Report Date:

2014-09-01

Pagination or Media Count:

24.0

Abstract:

Considerable progress has been made during the past budget cycle on all of the specific tasks set forth in the SOW for the present proposal. The overarching goal of Specific Aim 1 months 0-12 of award has been accomplished, with the identification of a novel metabolomics protein signature of Gamitrinib anticancer activity, in vivo i, the characterization of protein biomarkers of Gamitrinib function in genetic models of prostate cancer ii, and the further biochemical characterization of the target of Gamitrinib, TRAP-,1 in tumor bioenergetics and metabolic reprogramming iii. Altogether, the work supported by the present award led to the publication of two articles directly relevant to the scopes of the present SOW Chae et al Nat Comm. 42139 Lisanti et al Cell Rep 6177, the submission for publication of a third original article Ghosh et al submitted, and the presentation of some of the SOW research findings at a national conference Keystone Conference on Mitochondrial Dynamics and Physiology, Santa Fe, NM -1822014 2322014.

Descriptors:

• *CANCER
• *MITOCHONDRIA
• *PHARMACOKINETICS
• BUDGETS
• CLINICAL MEDICINE
• COLLAPSE
• PENETRATION
• PROSTATE CANCER
• TOXICOLOGY

Subject Categories:

• Anatomy and Physiology
• Medicine and Medical Research
• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE