Regulation of Mitochondria Function by TRAF3 in B Lymphocytes and B Cell Malignancies
Annual rept. 1 Aug 2013-31 Jul 2014
RUTGERS - THE STATE UNIV NEW BRUNSWICK NJ
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This project aims to investigate how a new tumor suppressor gene, TRAF3, regulates mitochondria function in B lymphocytes and B cell malignancies. TRAF3 deletions and mutations occur in a variety of B cell malignancies, including B cell chronic lymphocytic leukemia B-CLL, non-Hodgkin lymphoma NHL, such as splenic marginal zone lymphoma and mantle cell lymphoma, multiple myeloma MM, and Waldenstr m s macroglobulinemia. We found that specific deletion of TRAF3 from B lymphocytes results in remarkably prolonged survival of mature B cells, which eventually leads to development of splenic marginal zone lymphoma or B1 lymphoma in mice. In this context, understanding how TRAF3 promotes B cell apoptosis is critical for rational design of therapeutic intervention of human B cell neoplasms. In pursuing such underlying mechanisms, we have obtained an unexpected but highly interesting finding.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research