Accession Number:

ADA610687

Title:

Regulation of Mitochondria Function by TRAF3 in B Lymphocytes and B Cell Malignancies

Descriptive Note:

Annual rept. 1 Aug 2013-31 Jul 2014

Corporate Author:

RUTGERS - THE STATE UNIV NEW BRUNSWICK NJ

Personal Author(s):

Report Date:

2014-08-01

Pagination or Media Count:

100.0

Abstract:

This project aims to investigate how a new tumor suppressor gene, TRAF3, regulates mitochondria function in B lymphocytes and B cell malignancies. TRAF3 deletions and mutations occur in a variety of B cell malignancies, including B cell chronic lymphocytic leukemia B-CLL, non-Hodgkin lymphoma NHL, such as splenic marginal zone lymphoma and mantle cell lymphoma, multiple myeloma MM, and Waldenstr m s macroglobulinemia. We found that specific deletion of TRAF3 from B lymphocytes results in remarkably prolonged survival of mature B cells, which eventually leads to development of splenic marginal zone lymphoma or B1 lymphoma in mice. In this context, understanding how TRAF3 promotes B cell apoptosis is critical for rational design of therapeutic intervention of human B cell neoplasms. In pursuing such underlying mechanisms, we have obtained an unexpected but highly interesting finding.

Subject Categories:

  • Biochemistry
  • Genetic Engineering and Molecular Biology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE