Accession Number:

ADA610649

Title:

Exploring the Pathogenic and Therapeutic Implications of Aberrant Splicing in Breast Cancer

Descriptive Note:

Final scientific rept. 1 Jul 2008-30 Jun 2011

Corporate Author:

DUKE UNIV DURHAM NC

Personal Author(s):

Report Date:

2011-07-01

Pagination or Media Count:

12.0

Abstract:

In this proposal, we aimed to a systematically monitor splicing variant profiles in breast cancer susceptibility genes and b explore the role of alternative splicing in breast chemotherapy using a global strategy. In doing so, we hoped to identify and validate candidate splicing variants involved in tumorigenesis using deep sequencing and functional assays.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE