Exploring the Pathogenic and Therapeutic Implications of Aberrant Splicing in Breast Cancer
Final scientific rept. 1 Jul 2008-30 Jun 2011
DUKE UNIV DURHAM NC
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In this proposal, we aimed to a systematically monitor splicing variant profiles in breast cancer susceptibility genes and b explore the role of alternative splicing in breast chemotherapy using a global strategy. In doing so, we hoped to identify and validate candidate splicing variants involved in tumorigenesis using deep sequencing and functional assays.
- Anatomy and Physiology
- Medicine and Medical Research