Development of Magnetic Resonance Imaging Biomarkers for Traumatic Brain Injury
Final addendum rept. 2 Jun 2011-1 Jun 2014
WAYNE STATE UNIV DETROIT MI
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The purpose of this research program was to develop an imaging-based protocol to improve diagnosis and outcome prediction of mild traumatic brain injury mTBI. In our technical program, we developed susceptibility weighted imaging and mapping SWIM as a means to quantify cerebral hemorrhage and venous blood oxygenation. By translating this work into mTBI patients, along with other imaging techniques, we made significant achievements. First, we demonstrated that these new advanced MRI methods complement conventional imaging methods in their ability to detect mTBI in the acute setting. Second, susceptibility weighted imaging and mapping SWIM are able to delineate venous structures and microbleeds making it possible to quantify and monitor evolution of pathological changes. And third, we have combined SWIM with other advanced imaging techniques, including diffusion tensor imaging, functional MRI, and perfusion imaging, to improve the detection of mTBI. The significance of this work to date is that we are now able to find evidence of damage in mTBI where that has heretofore been difficult with conventional MRI. Finally, we have developed SWIM as a tool for clinical TBI detection and quantification.
- Medicine and Medical Research