Prospective Evaluation of Intraprostatic Inflammation and Focal Atrophy as a Predictor of Risk of High-Grade Prostate Cancer and Recurrence after Prostatectomy
Annual progress rept. 1 Jul 2013-30 Jun 2014
JOHNS HOPKINS UNIV BALTIMORE MD BLOOMBERG SCHOOL OF PUBLIC HEALTH
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We are evaluating, in two nested case-control studies, intraprostatic inflammation and focal atrophy, a prostate lesion that is often inflamed, as tissue markers for risk of future diagnosis of high-grade prostate cancer, and for prognosis at the time of surgery for clinically localized prostate cancer. For prostate cancer incidence, in Year 2, we completed the pathology review of inflammation and focal atrophy the HE stained biopsy core images for the linked PCPT-SELECT data incident prostate cancer. We worked with the Fred Hutchinson Cancer Research Center subcontractor to identify and generate needed covariates for the statistical analysis. We performed a preliminary analysis of the overall prevalence of inflammation and atrophy. To make the work more efficient, we have optimized a higher-throughput method for image analysis of the immunohistochemical stained slides than we had originally proposed. We documented the comparability of the counts from the image analysis method and manual visual counting for one of the markers. Our work is progressing slower than as proposed in the Statement of Work, but results are being produced, and with state-of-the art technology.
- Medicine and Medical Research