Optimization and Implementation of Long Nerve Allografts
Annual rept. 1 Feb 2013-31 Jan 2014
FLORIDA UNIV GAINESVILLE
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Loss of nerve function occurs when a nerve is severed. Any significant loss of nerve tissue requires a graft to restore continuity and promote nerve regeneration and recovery of function. Presently, there is no acceptable nerve grafting method for the repair of extensive nerve damage. An acellular nerve allograft product is available for the reconstruction of short to moderate length nerve defects, however, in its present from the allograft is not suitable for the repair of lengthy nerve defects. The aims of this project are to evaluate several long 7cm nerve allograft technologies. All experimental tasks scheduled for years 1 and 2 were completed. A 6-month no-cost extension was approved to complete the extensive data analyses and documentation. An overview of findings indicates that the SIS-graft provided for nerve regeneration and meaningful recovering of nerve function that, in several cases was better than autografting. Other decellularized allografts tested did not perform well in this repair model. Additional evaluations and data analyses are ongoing to determine the efficacy and failures observed.
- Medicine and Medical Research