Accession Number:

ADA609597

Title:

Cell Lineage Analysis of Mouse Prostate Carcinogenesis

Descriptive Note:

Annual rept. 1 Jul 2013-30 Jun 2014

Corporate Author:

PITTSBURGH UNIV PA

Personal Author(s):

Report Date:

2014-07-01

Pagination or Media Count:

7.0

Abstract:

Defining the origin of prostate cancer cells is fundamentally important and will guide future research to focus on cells from which prostate cancer cells are derived. Prostate cancer is thought to be derived from luminal epithelial cells in the prostate, because a hallmark of prostate cancer is the loss of basal epithelial cells and prostate cancer cells exhibit a luminal epithelial cell phenotype including the expression of AR and PSA. However, the luminal origin of prostate cancer has been challenged by a number of recent publications. This project will determine whether prostate cancer cells are derived from luminal or basal epithelial cells in an EAF2-- PTEN- mouse model, and determine whether luminal-derived prostate cancer cells behave differently from basal-derived prostate cancer cells. In the last year of the funding period, we have generated 2 breeding pairs consisting of 1 male and 1 female for Specific Aim 1, and 6 breeding pairs for Specific Aim 2.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE