Accession Number:

ADA609564

Title:

White Matter Hyperintensities on MRI in High-Altitude U-2 Pilots

Descriptive Note:

Journal article

Corporate Author:

SCHOOL OF AEROSPACE MEDICINE WRIGHT PATTERSON AFB OH

Report Date:

2013-08-19

Pagination or Media Count:

9.0

Abstract:

The purpose of this study was to demonstrate that U-2 pilot occupational exposure to hypobaria leads to increased incidence of white matter hyperintensities WMH with a more uniform distribution throughout the brain irrespective of clinical neurologic decompression sickness history. We evaluated imaging findings in 102 U-2 pilots and 91 controls matched for age, health, and education levels. Three-dimensional, T2-weighted, high-resolution 1-mm isotropic imaging data were collected using fluid-attenuated inversion recovery sequence on a 3-tesla magnetic resonance imaging scanner. Whole-brain and regional WMH volume and number were compared between groups using a 2-tailed Wilcoxon rank sum test. U-2 pilots demonstrated an increase in volume 394 p 0.004 and number 295 p 0.001 of WMH. Analysis of regional distribution demonstrated WMH more uniformly distributed throughout the brain in U-2 pilots compared with mainly frontal distribution in controls. Pilots with occupational exposure to hypobaria showed a significant increase in WMH lesion volume and number. Unlike the healthy controls with predominantly WMH in the frontal white matter, WMH in pilots were more uniformly distributed throughout the brain. This is consistent with our hypothesized pattern of damage produced by interaction between microemboli and cerebral tissue, leading to thrombosis, coagulation, inflammation, andor activation of innate immune response, although further studies will be necessary to clarify the pathologic mechanisms responsible.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research
  • Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE