Accession Number:

ADA609497

Title:

Wnt/beta-Catenin, Foxa2, and CXCR4 Axis Controls Prostate Cancer Progression

Descriptive Note:

Annual rept. 1 Jul 2013-30 Jun 2014

Corporate Author:

VANDERBILT UNIV NASHVILLE TN

Personal Author(s):

Report Date:

2014-07-01

Pagination or Media Count:

10.0

Abstract:

Wntbeta-Catenin signaling and associated target genes are implicated in the establishment of bone metastasis and in the development of castration resistant prostate cancer. Our previous studies have shown that Foxa2 is a Wntbeta-catenin target gene in prostates. Our preliminary study suggests a Wnt Foxa2 CXCR4 axis that is involved in PCa bone metastasis, and activation of this axis provides survival mechanisms for PCa cells following androgen deprivation. The hypothesis is that the Wntbeta-catenin activation of Foxa2 and CXCR4 promotes progression to CRPCa and facilitates bone colonization by PCa cells, and that targeting this axis will provide a novel treatment for PCa bone metastasis and relapse after androgen ablation. In the past one year, our effort mainly focused on addressing if active Wntbeta-Catenin signaling-induced expression of Foxa2 promotes castration resistant prostate cancer grow in vivo task 1b if Foxa2 is involved in the interaction of prostate cancer cells and bone microenvironment task 2a and if over-expression of Foxa2 facilitates prostate cancer growth in the bone and progression to castration resistance task 2b.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE