Accession Number:

ADA609161

Title:

Therapeutic Remyelination Strategies in a Novel Model of Multiple Sclerosis: Japanese Macaque Encephalomyelitis

Descriptive Note:

Annual rept. 1 May 2011-30 Apr 2012

Corporate Author:

OREGON HEALTH AND SCIENCE UNIV BEAVERTON

Report Date:

2012-05-01

Pagination or Media Count:

27.0

Abstract:

During the second year of this grant, we have finished characterizing the spontaneous form of Japanese macaque encephalomyelitis JME and published a manuscript in Annals of Neurology describing our results we have characterized how intracranial injections of the Japanese macaque rhadinovirus JMRV induce demyelinating disease, as assessed by histopathology, MRI, and symptoms we have demonstrated both in vitro and in vivo which cells are affected by JMRV infection we have performed additional analyses characterizing the immune response to JMRV infection and we have continued our genetic analyses. In the next year, we will continue to analyze the mechanisms by which JMRV triggers disease onset and immune responses and the role of the cytopathic effects of the virus in this process, which genes are linked to disease susceptibility, and how the virus influences cells in lesion microenvironments.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE