Magnetic Resonance-Based Electrical Property Tomography (MR- EPT) for Prostate Cancer Grade Imaging
Annual rept. 1 Jul 2013-30 Jun 2014
TRUSTEES OF DARTMOUTH COLL HANOVER NH OFFICE OF SPONSORED PROJECTS
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Determining whether a man recently diagnosed with prostate cancer has aggressive disease requiring immediately radical therapy or indolent disease requiring a more passive watchful waiting or active surveillance approach is a current clinical challenge. This technology development study is focused on developing Magnetic Resonance Electrical Property Tomography MR-EPT specifically for prostate imaging. MR-EPT is an imaging modality that may enable clinicians to image the electrical properties of prostate at near MR resolution. These electrical properties are hypothesized to provide sufficient contrast for distinguishing between aggressive and indolent prostate cancer. Much of the first year of this program has focused on MR sequence optimization, MR-EPT image reconstruction algorithm development and optimization, experimental imaging of both simplistic and anatomically accurate phantoms, and initial ex vivo prostate imaging. During this year we have optimized our MR-EPT sequences, demonstrated the imaging capabilities of MR-EPT through phantom studies, and have produced the first conductivity images of ex vivo prostate using MR-EPT techniques. The second year of the program will primarily focus on ex vivo and in vivo data acquisition, statistical analysis of our data, and preparation of publications and proposals for follow-on more clinically focused studies.
- Medicine and Medical Research