Early Events in Ovarian Cancer Pathogenesis
Final rept. 15 Oct 2009-14 Oct 2011
M D ANDERSON CANCER CENTER HOUSTON TX
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A clear understanding of the molecular and biological events that occur early in the development of ovarian cancer would provide a basis for rational treatment and prevention. We have assembled a group of highly experienced investigators to systematically address these questions. During the funding period, we have developed the full Consortium grant according to the following three areas 1 Molecular signatures of early tubal carcinogenesis. This project, led by Dr. Chris Crum, will validate the precursor sequence and identify markers of early malignancy based on expression or epigenetic profiles. 2 Identification of early molecular events in the pathogenesis of BRCA1 and BRCA2 associated ovarian cancer. This project, led by Dr. Karen Lu, will define the early molecular events in pathogenesis of BRCA1 and BRCA2 associated ovarian cancer and develop in vivo molecular imaging techniques for early detection. 3 Functional characterization of genes involved in fallopian tube cancer initiation, progression, and metastasis. This project, led by Dr. Sandra Orsulic, focuses on in vitro and in vivo functional characterization of genes that are suspected to play a role in tubal cancer. The proposed work described above is supported by the following Cores 1 Administrative Core 2 PathologyGenomics Core and 3 Biostatistics Core.
- Medicine and Medical Research