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Photoacoustic Imaging of Epilepsy

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Final rept. 1 Apr 2009-31 Mar 2014

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This research is aimed at developing a new imaging approach, called Photoacoustic tomography PAT , for non-invasively tracking dynamical changes during seizure occurrence. The project will develop imaging hardware and software, and conduct phantomin vivo experiments to achieve the proposed goals. We have fulfilled the statement of work proposed. The real-time PAT system completed in Years 1 and 2 provides us a platform for performing the extensive phantom and animal experiments proposed for the coming years. In year 3, we implemented reconstruction codes and we performed simulation and phantom experiments to evaluate the software developments. In year 4, the real-time PAT system constructed in this project coupled with the light-weighted cap interface has provided us a platform for performing extensive animal experiments in freely moving rats. In Year 5 we completed the proposed Tasks 6 and 7 for continuous recording of EEG and PAT over a long period of time to monitor seizure activity continuously to characterize changes during interictal, ictal and post-ictal periods when a spontaneous seizure occurs. We analyzed the images from the in vivo experiments and wrote the final report. We completed any unfinished experimentation during these months such that we have a sufficient number or rats monitored with EEG and PAT to reach statistical significance.

Subject Categories:

  • Medicine and Medical Research
  • Optics

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