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Acute Dermal Irritation Study of Ten Jet Fuels in New Zealand White Rabbits: Comparison of Synthetic and Bio-Based Jet Fuels with Petroleum JP-8
Interim rept. Jul 2009-Aug 2010
AIR FORCE RESEARCH LAB WRIGHT PATTERSON AFB OH HUMAN PERFORMANCE WING (711TH) HUMAN EFFECTIVENESS DIR/ BIOEFFECTS DIVISION
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The dermal irritation potential of ten jet fuels of interest to the U.S. Air Force was studied, including petroleum-derived JP-8. Five of the alternative fuels were synthetic paraffinic kerosenes SPK derived from non-petroleum fossil fuel feedstocks utilizing a Fischer-Tropsch synthesis FT-SPK Sasol iso-paraffinic kerosene IPK, Sasol gas to liquid GTL-1 and GTL-2, Shell GTL and Syntroleum S-8 synthetic JP-8. Four fuels were renewable bio-based fuels Syntroleum R-8 hydroprocessed esters and fatty acids jet fuel derived from mixed fats and oils HEFA-F, Syntroleum Sapphire derived from algae HEFA-A, Amyris IPK and Swedish Biofuel. Each fuel was applied for four hours to the skin of New Zealand White NZW rabbits using occluded or semi-occluded exposures, and evaluated by the Draize method. A score of slightly irritating was determined for the occluded and semi-occluded exposures to all test substances, with the exception of a score of non-irritating for the semi-occluded exposures of Sasol IPK, SyntroleumS-8 and HEFA-F. Very slight erythema persisted through study day 14 for the occluded exposures to Amyris IPK, Swedish Biofuel, and HEFA-A. Normal handling of these fuels should not result in increased dermal irritation among airmen.
APPROVED FOR PUBLIC RELEASE