Accession Number:

ADA604627

Title:

Molecular and Cellular Mechanisms of Pressure Induced Ca2+-Mediated Impairments of the Central Nervous System

Descriptive Note:

Final rept. 8 Nov 2009-31 Dec 2013

Corporate Author:

BEN-GURION UNIV OF THE NEGEV BEERSHEBA (ISRAEL)

Personal Author(s):

• Grossman, Yoram

Report Date:

2014-04-09

Pagination or Media Count:

1.0

Abstract:

Hyperbaric environments present many physiological challenges, especially affecting the lungs, hollow viscera and the nervous system. Under pressure, soft tissues of the body behave as a fluid and rapidly transmit any pressure applied against the surface of the body to the adjacent fluid compartments. This results in hydrostatic compression of the cerebral spinal fluid, cerebral circulation, and extracellular and intracellular fluid compartments of the mammalian CNS. Thus, practically every cell is exposed to the ambient pressure.

Descriptors:

• *EXPOSURE(PHYSIOLOGY)
• *HYPERBARIC CONDITIONS
• *PHYSIOLOGICAL EFFECTS
• BRAIN FUNCTION IMPAIRMENT
• CALCIUM
• CELLS
• CENTRAL NERVOUS SYSTEM
• CEREBRUM
• COMPRESSION
• CYTOLOGY
• HIPPOCAMPUS
• MAGNESIUM
• MODULATION
• MOLECULES
• NEUROMUSCULAR TRANSMISSION
• NEUROPHYSIOLOGY
• NEUROSCIENCE
• PRESSURE
• SOFT TISSUES
• SYNAPSE

Subject Categories:

• Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE