Accession Number:

ADA604606

Title:

The Function of Neuroendocrine Cells in Prostate Cancer

Descriptive Note:

Annual rept. 1 Apr 2013-31 Mar 2014

Corporate Author:

CALIFORNIA UNIV LOS ANGELES

Personal Author(s):

Report Date:

2014-04-01

Pagination or Media Count:

16.0

Abstract:

The goal of the project is to determine the function of neuroendocrine NE cells in the initiation and progression of human prostate cancer 1 Use a pten null mouse prostate cancer model to determine if ablation of NE cells by selective expression of a toxin in these cells can delay or prevent tumor initiation andor progression. 2 Use a human tissue recombination model to determine if depletion of NE cells from human epithelial cells can retard the initiation and progression of the recombinant tumor. 3. Demonstrating the origin and molecular basis of human small cell carcinoma 1. We have successfully completed the vast majority of the research tasks 2. We are in the process of restoring transgenic mice expressing toxin to complete task 1c 3. We are in the process of optimizing tissue collection method to complete task 3c.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE