Accession Number:

ADA604404

Title:

The Isolation and Characterization of Human Prostate Cancer Stem Cells

Descriptive Note:

Annual summary 29 Jan 2012-28 Jan 2013

Corporate Author:

MICHIGAN UNIV ANN ARBOR SCHOOL OF MEDICINE

Personal Author(s):

• Palapattu, Ganesh S.

Report Date:

2013-02-01

Pagination or Media Count:

10.0

Abstract:

The overall objective of this proposal is to develop a durable cure for lethal prostate cancer through the elucidation of the role of cancer stem cells in the pathogenesis of the disease. During the past year, we have made the following significant findingsobservations i3D culture of human prostate cancer cells with magnetic nanoparticles is not optimal for tumor initiation studies, ii in vitro co-culture of human prostate cancer cells established cell lines and primary patient samples with human prostate fibroblasts hold promise as models of tumor initiationcancer stem cell activity. We continue to optimize and validate our in vitro model of prostate cancer initiation to facilitate cancer stem cell discovery as well as drug targeting.

Descriptors:

• *PROSTATE CANCER
• *STEM CELLS
• DRUGS
• FIBROBLASTS
• IN VITRO ANALYSIS
• PATHOGENESIS

Subject Categories:

• Anatomy and Physiology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE