Microneedle Device Prototype
Final rept. 16 Jul 2012-31 May 2014
SANDIA NATIONAL LABS ALBUQUERQUE NM
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Real-time monitoring of an individuals physiological state without the constant presence of a healthcare professional would necessitate the construction of an autonomous remote diagnostic device that is capable of performing a wide range of diagnostic functions. For many applications, the immediate physiological state of a warfighter as he or she is continually exposed to diverse environments would require complex dynamic chemical processing scenarios that are capable of real-time readouts in order to maintain optimal health and effectiveness. The results presented here are an important proof-of-concept study to demonstrate how microneedles can be integrated with a microchip platform, complete with fluidic channels and electrode transducers, to extract interstitial fluid and monitor biologically important biomolecules toward a long-term remote diagnostic platform for defense of the warfighter. The project, part of a Defense Threat Reduction Agency research program, results consist of 1 microneedle fabrication, 2 electrode array fabrication, 3 optimization of the electrode array for construction of an immunoassay for detection of myoglobin and troponin, and 4 integration of microneedles and the electrode array in a packaged chip.
- Anatomy and Physiology
- Biomedical Instrumentation and Bioengineering