Accession Number:

ADA604248

Title:

Microneedle Device Prototype

Descriptive Note:

Final rept. 16 Jul 2012-31 May 2014

Corporate Author:

SANDIA NATIONAL LABS ALBUQUERQUE NM

Personal Author(s):

• Miller, Philip
• Moorman, Mathew
• Brozik, Susan
• Edwards, Thayne
• Wheeler, David
• Polsky, Ronen
• Narayan, Roger

Report Date:

2014-05-01

Pagination or Media Count:

25.0

Abstract:

Real-time monitoring of an individuals physiological state without the constant presence of a healthcare professional would necessitate the construction of an autonomous remote diagnostic device that is capable of performing a wide range of diagnostic functions. For many applications, the immediate physiological state of a warfighter as he or she is continually exposed to diverse environments would require complex dynamic chemical processing scenarios that are capable of real-time readouts in order to maintain optimal health and effectiveness. The results presented here are an important proof-of-concept study to demonstrate how microneedles can be integrated with a microchip platform, complete with fluidic channels and electrode transducers, to extract interstitial fluid and monitor biologically important biomolecules toward a long-term remote diagnostic platform for defense of the warfighter. The project, part of a Defense Threat Reduction Agency research program, results consist of 1 microneedle fabrication, 2 electrode array fabrication, 3 optimization of the electrode array for construction of an immunoassay for detection of myoglobin and troponin, and 4 integration of microneedles and the electrode array in a packaged chip.

Descriptors:

• *DIAGNOSTIC EQUIPMENT
• ANTIBODIES
• CHIPS(ELECTRONICS)
• ELECTRODES
• HEMOGLOBIN
• IMMUNOASSAY
• IN VIVO ANALYSIS
• MONITORING
• NEEDLES

Subject Categories:

• Biochemistry
• Anatomy and Physiology
• Biomedical Instrumentation and Bioengineering

Distribution Statement:

APPROVED FOR PUBLIC RELEASE