Accession Number:

ADA604089

Title:

Glutamate Signaling and Mitochondrial Dysfunction in Models of Parkinson's Disease

Descriptive Note:

Final rept. 1 Dec 2012-30 Nov 2013, Option year 2

Corporate Author:

NORTHWESTERN UNIV CHICAGO IL

Personal Author(s):

• Surmeier, D. J.

Report Date:

2014-03-01

Pagination or Media Count:

9.0

Abstract:

The central hypothesis of the proposal is that in the early stages of PD, an elevation in synaptically released glutamate leads to persistent activation of NMDARs that synergizes with Cav1 calcium channels to significantly increase mitochondrial oxidant stress and neurodegeneration.

Descriptors:

• *PARKINSONS DISEASE
• DEGENERATION(PHYSIOLOGY)
• DYSFUNCTION
• GLUTAMIC ACID
• MITOCHONDRIA
• SALTS
• STRESSES

Subject Categories:

• Anatomy and Physiology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE