Novel Therapeutic Approaches Toward Treating Prostate Cancer
Final rept. 15 Apr 2010-14 Apr 2013
MEDICAL UNIV OF SOUTH CAROLINA CHARLESTON
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This proposal has evaluated the activity of the Pim protein kinase. This enzyme has been shown to function with the c-Myc protein and enhance tumor growth. It is possible that Pim enhanced the growth of tumor cells by stimulating growth and then also decreasing proteins that would normally inhibit the growth of cells. The goals of this research were to study the ability of Pim to regulate hepatocyte growth factor cMet signaling, examine the regulation of the p27 cell cycle inhibitory protein by Pim, and investigate the interaction of the Pim and AKT pathways in driving Pim mediated growth. The results of these studies have led to an understanding of Pim-1 mechanism of action and three publications in peer-reviewed journals. In this report, these findings are detailed with a focus on the ability of Pim to upregulate c-Met, downregulate p27, and enhance protein synthesis in the face of AKT inhibition.
- Anatomy and Physiology
- Medicine and Medical Research