DID YOU KNOW? DTIC has over 3.5 million final reports on DoD funded research, development, test, and evaluation activities available to our registered users. Click
HERE to register or log in.
Accession Number:
ADA601643
Title:
Regenerative Medicine and Restoration of Joint Function
Descriptive Note:
Annual rept. 27 Sep 2012-26 Sep 2013
Corporate Author:
MOUNT SINAI HOSPITAL TORONTO (ONTARIO) SAMUEL LUNENFIELD RESEARCH INST
Report Date:
2013-10-01
Pagination or Media Count:
146.0
Abstract:
Currently amputation, arthrodesis joint fusion, or joint replacement are used to treat a joint with an intra-articular fracture or destroyed by a combat injury. Generation of personalized, anatomically shaped biological implants formed using techniques of regenerative medicine in conjunction with biodegradable biomaterial structures to restore a damaged articular joint surface to normal tissue structure, form and function is one way to overcome the limitations associated with current treatment methods. The aims of this study are to 1 identify the parameters that generate anatomically shaped bone substitutes of optimal composition and structure with an articulating profile. 2 to develop a source of chondrocytes that can generate sufficient amounts of a cartilage layer to cover the bone substitute and 3 to evaluate the structures formed in a preclinical model. The ongoing studies will further our understanding of the regulation of cell differentiation to chondrocytes and the bone substitute properties required to form a biological joint replacement.
Distribution Statement:
APPROVED FOR PUBLIC RELEASE