Regenerative Medicine and Restoration of Joint Function
Annual rept. 27 Sep 2012-26 Sep 2013
MOUNT SINAI HOSPITAL TORONTO (ONTARIO) SAMUEL LUNENFIELD RESEARCH INST
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Currently amputation, arthrodesis joint fusion, or joint replacement are used to treat a joint with an intra-articular fracture or destroyed by a combat injury. Generation of personalized, anatomically shaped biological implants formed using techniques of regenerative medicine in conjunction with biodegradable biomaterial structures to restore a damaged articular joint surface to normal tissue structure, form and function is one way to overcome the limitations associated with current treatment methods. The aims of this study are to 1 identify the parameters that generate anatomically shaped bone substitutes of optimal composition and structure with an articulating profile. 2 to develop a source of chondrocytes that can generate sufficient amounts of a cartilage layer to cover the bone substitute and 3 to evaluate the structures formed in a preclinical model. The ongoing studies will further our understanding of the regulation of cell differentiation to chondrocytes and the bone substitute properties required to form a biological joint replacement.
- Medicine and Medical Research