Accession Number:

ADA599233

Title:

Aspm, a Key Element in Medulloblastoma Pathogenesis and a Novel Target for Treatment

Descriptive Note:

Final rept. 30 Sep 2012-29 Sep 2013

Corporate Author:

NORTH CAROLINA UNIV AT CHAPEL HILL

Personal Author(s):

Report Date:

2013-10-01

Pagination or Media Count:

35.0

Abstract:

Medulloblastoma is the most common malignant brain tumor in children. We have found that Aspm, a gene required for normal brain growth in early childhood, becomes co-opted during medulloblastoma formation, to support tumor growth. We have found that Aspm supports growth by reducing stress to genomic DNA when cells divide. We have further found that targeting Aspm can reduce medulloblastoma growth.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE