Aspm, a Key Element in Medulloblastoma Pathogenesis and a Novel Target for Treatment
Final rept. 30 Sep 2012-29 Sep 2013
NORTH CAROLINA UNIV AT CHAPEL HILL
Pagination or Media Count:
Medulloblastoma is the most common malignant brain tumor in children. We have found that Aspm, a gene required for normal brain growth in early childhood, becomes co-opted during medulloblastoma formation, to support tumor growth. We have found that Aspm supports growth by reducing stress to genomic DNA when cells divide. We have further found that targeting Aspm can reduce medulloblastoma growth.
- Medicine and Medical Research