Accession Number:

ADA596894

Title:

High-Throughput Screening of Compounds for Anti-Transmissible Spongiform Encephalopathy Activity Using Cell-Culture and Cell-Free Models and Infected Animals

Descriptive Note:

Final rept. 18 Jun 2003 - 17 Jun 2008

Corporate Author:

NATIONAL INST OF ALLERGY AND INFECTIOUS DISEASES HAMILTON MT ROCKY MOUNTAIN LAB

Personal Author(s):

• Caughey, Byron
• Kocisko, David

Report Date:

2008-07-01

Pagination or Media Count:

107.0

Abstract:

Transmissible spongiform encephalopathies TSEs or prion diseases are fatal, transmissible and untreatable neurodegenerative diseases of humans and animals. To aid in the search for anti-TSE therapeutics, we have 1 developed new relatively high through-put in vitro drug screens, 2 assayed large numbers of previously untested compounds as TSE inhibitors, 3 identified numerous new prionPrPSc inhibitors in vitro and in vivo, and 4 developed a new unified mechanistic model for the activity of various classes of PrPSc inhibitors which is consistent with a considerable body of evidence from our laboratory and others.

Descriptors:

• *CELLS
• *CULTURES(BIOLOGY)
• *ENCEPHALITIS
• ANIMALS
• DISEASES
• DRUGS
• IN VITRO ANALYSIS
• IN VIVO ANALYSIS
• INFECTIOUS DISEASE TRANSMISSION
• INHIBITORS
• LABORATORIES

Subject Categories:

• Biology
• Anatomy and Physiology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE