High-Throughput Screening of Compounds for Anti-Transmissible Spongiform Encephalopathy Activity Using Cell-Culture and Cell-Free Models and Infected Animals
Final rept. 18 Jun 2003 - 17 Jun 2008
NATIONAL INST OF ALLERGY AND INFECTIOUS DISEASES HAMILTON MT ROCKY MOUNTAIN LAB
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Transmissible spongiform encephalopathies TSEs or prion diseases are fatal, transmissible and untreatable neurodegenerative diseases of humans and animals. To aid in the search for anti-TSE therapeutics, we have 1 developed new relatively high through-put in vitro drug screens, 2 assayed large numbers of previously untested compounds as TSE inhibitors, 3 identified numerous new prionPrPSc inhibitors in vitro and in vivo, and 4 developed a new unified mechanistic model for the activity of various classes of PrPSc inhibitors which is consistent with a considerable body of evidence from our laboratory and others.
- Anatomy and Physiology
- Medicine and Medical Research