Accession Number:

ADA595907

Title:

Identification of Small Molecule Inhibitors of microRNA Involved in Chemoresistance and Cancer Stem Cells for Ovarian Cancer Intervention

Descriptive Note:

Final rept. 1 Mar 2011-31 Aug 2013

Corporate Author:

H LEE MOFFITT CANCER CENTER AND RESEARCH INST TAMPA FL

Personal Author(s):

Report Date:

2013-09-01

Pagination or Media Count:

12.0

Abstract:

During last year, we have characterized a small molecule inhibitor MIR214-I of miR-214. MIR214-I was found to specifically bind to miR-214 in vitro and in vivo. Furthermore, MIR214-I induces programmed cell death and inhibits ovarian cancer stem cell renewal in ovarian cancer cells expressing high levels of miR-214. In addition, MIR214-I selectively reduces tumor growth in xenograft model. Notably, MIR214-I synergizes with cisplatin and overcomes cisplatin resistance.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE