Accession Number:

ADA595619

Title:

Subharmonic Imaging and Pressure Estimation for Monitoring Neoadjuvant Chemotherapy

Descriptive Note:

Annual rept. 1 Sep 2012-31 Aug 2013

Corporate Author:

THOMAS JEFFERSON UNIV PHILADELPHIA PA

Personal Author(s):

Report Date:

2013-09-01

Pagination or Media Count:

11.0

Abstract:

Neoadjuvant chemotherapy is currently the standard of care for locally advanced breast cancer LABC. Monitoring tumor response is advantageous for patients. This project aims to using the subharmonic signals from ultrasound contrast agents to improve the monitoring of breast cancer treatment response to neoadjuvant therapies in women diagnosed with LABC by imaging tumor angiogenesis with 3D subharmonic imaging SHI and by estimating the interstitial fluid pressure IFP using 3D subharmonic aided pressure estimation SHAPE. To date, software for analyzing RF data from a Logiq 9 ultrasound scanner GE Healthcare, Milwauke, WI to produce 3D SHAPE pressure estimates has been successfully developed. Initial in vivo experiments in 2 canines have been completed. SHI and the optimization algorithm implemented indicate that the use of SHAPE for noninvasive evaluation of the IFP in breast lesions is feasible with Definity. Moreover, However, difficulty in obtaining the necessary approvals for our human clinical trial has delayed the project by approximately 8 months.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE