Accession Number:

ADA595512

Title:

Bone Repair and Military Readiness

Descriptive Note:

Annual rept. 20 Sep 2012-19 Sep 2013

Corporate Author:

MISSOURI UNIV-KANSAS CITY

Personal Author(s):

Report Date:

2013-10-19

Pagination or Media Count:

18.0

Abstract:

Even though commercial bone cements have not significantly changed in the past 50 years and have been used throughout the world, there are significant drawbacks with the current systems. We have developed a silorane based resin superior to polymethyl methacrylate PNMA with many improved properties such as significantly less polymerization stress although an associated reduction in mechanical properties. The specific aims for this project are Specific Aim 1 Develop a silorane bone cement suitable for in vivo studies and to optimize the formulation of the chemically and mixed cured cement prototypes. Specific Aim 2 Determine the biocompatibility properties and wear debris generation of silorane bone cement prototype. Specific Aim 3 Determine the biological response to silorane bone cement prototype in animal models. By addressing the shortcomings of current PMMA bone cement, the development of the novel silorane bone cement will result in a paradigm shift in orthopedic biomaterials.

Subject Categories:

  • Biology
  • Pharmacology
  • Inorganic Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE