Effects of Enhanced Oxygen Delivery by Perfluorocarbons in Spinal Cord Injury
Final rept. 1 Jan 2011-30 Sep 2013
VIRGINIA COMMONWEALTH UNIV MEDICAL CENTER RICHMOND
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As the incidence of spinal cord injury has increased in the combatant military population, improved methods of treating this clinical condition are necessary. Given our previous work with measuring the pO2 in CSF and the parenchyma, following the administration of perfluorocarbons in an acute spinal cord injury model, we elected to further the study by performing behavioral studies, and histopathology at multiple time points post injury. Our aim is to determine if enhanced oxygen delivery in spinal cord injury will improve functional recovery in a rodent spinal cord injury model. We hypothesize that the delivery of perfluorocarbons will diminish the loss of spinal cord parenchymal tissue, and improve ambulation and sensory function. We hypothesize that markers of cell degeneration and apoptotis will be decreased as well.
- Medicine and Medical Research