The Use of Drugs to Reduce Hearing Loss Following Acute Acoustic Trauma
Final rept. 25 Jun 2010-24 Oct 2013
STATE UNIV OF NEW YORK COLL AT PLATTSBURGH
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The goal of this research was to compare, in the rescue mode of treatment, the effectiveness of 1 L-N-acetylcysteine L-NAC 2 D-Methionine D-MET 3 Ebselen SPI-1005 4 Acetyl-L-carnitine ALCAR and 5 Src-PTK inhibitor, KX1-004 in reducing hearing and sensory cell loss as the result of an acute acoustic trauma that simulates blast injury to the auditory system. A shock tube was used to produce a blast injury to the cochlea in a chinchilla model. A secondary goal was to apply the same drug administration protocol to groups of animals exposed to a lower level continuous noise. Data from the treated and control animals consisted of 1 auditory evoked potential hearing thresholds 2 cubic distortion product otoacoustic emissions DPOAE inputoutput functions along with DPOAEs as a function of frequency DPEgram to estimate sensory cell function 3 tympanograms to screen for conductive changes 4 surface preparation histology to estimate the frequency specific sensory cell loss. Statistical analysis of the data employed a mixed model analyses of variance with repeated measures on one factor frequency using the SPSS Release 4.0 statistical package. Results 1 There were no statistically significant differences between drug treated groups and controls. 2 There was a very large inter subject variability for all exposure groups.
- Medicine and Medical Research
- Stress Physiology